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VCAM-1 Antibody 26 Publications

Rabbit Polyclonal| Catalog number: 11444-1-AP

Featured Product KD/KO validated

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Con: 34 μg/150 μl

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Tested Applications

Applications:
IHC, IF, FC, ELISA
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VCAM-1 Antibody IHC human tonsillitis tissue 11444-1-AP

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 11444-1-AP (VCAM-1 antibody) at dilution of 1:600 (under 10x lens) heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

VCAM-1 Antibody IHC human tonsillitis tissue 11444-1-AP

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 11444-1-AP (VCAM-1 antibody) at dilution of 1:600 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

Species specificity:
human
Positive IHC detected in:
human tonsillitis tissue, human kidney tissue, human spleen tissue, human placenta tissue, human lung cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Recommended dilution:
IHC : 1:300-1:1200

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
VCAM-1 fusion protein Ag1993
Full name:
vascular cell adhesion molecule 1
Calculated molecular weight:
739aa,81 kDa
Observed molecular weight:
GenBank accession number:
BC017276
Gene ID (NCBI):
7412
Gene symbol
VCAM1
Synonyms
CD106, INCAM 100, V CAM 1, VCAM 1, VCAM1

Background

Vascular cell adhesion molecule 1 (VCAM1), also known as CD106, is a 110-kDa transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. VCAM1 is expressed by cytokine-activated endothelium, interacts with integrin VLA4 (α4β1) present on the surface of leukocytes, and mediates both adhesion and signal transduction. It is also expressed either constitutively or inducibly in a variety of other cell types, including vascular smooth muscle cells, differentiating skeletal muscle cells, renal and neural epithelial cells, macrophages (Kupffer cells), dendritic cells, and bone marrow stromal cells (PMID: 7507076, 11359843).


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