Validation Data Gallery
|Positive IHC detected in||human tonsillitis tissue, human kidney tissue, human spleen tissue, human placenta tissue, human lung cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Immunohistochemistry (IHC)||IHC : 1:400-1:1600|
|Sample-dependent, check data in validation data gallery|
11444-1-AP targets VCAM-1 in IHC, IF, FC, ELISA applications and shows reactivity with human samples.
|Host / Isotype||Rabbit / IgG|
|Immunogen||VCAM-1 fusion protein Ag1993|
|Full Name||vascular cell adhesion molecule 1|
|Calculated molecular weight||739 aa, 81 kDa|
|GenBank accession number||BC017276|
|Gene ID (NCBI)||7412|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Vascular cell adhesion molecule 1 (VCAM1), also known as CD106, is a 110-kDa transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. VCAM1 is expressed by cytokine-activated endothelium, interacts with integrin VLA4 (α4β1) present on the surface of leukocytes, and mediates both adhesion and signal transduction. It is also expressed either constitutively or inducibly in a variety of other cell types, including vascular smooth muscle cells, differentiating skeletal muscle cells, renal and neural epithelial cells, macrophages (Kupffer cells), dendritic cells, and bone marrow stromal cells (PMID: 7507076, 11359843).
Fra-1 plays a critical role in angiotensin II-induced vascular senescence.
Cell Death Dis
Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer.
J Cardiovasc Pharmacol Ther
Chrysin Suppresses Vascular Endothelial Inflammation via Inhibiting the NF-κB Signaling Pathway.
Biochem Biophys Res Commun
Cyclophilin D deficiency protects against the development of mitochondrial ROS and cellular inflammation in aorta.
HDAC4 regulates vascular inflammation via activation of autophagy.
Acta Biochim Biophys Sin (Shanghai)
SET8 is involved in the regulation of hyperglycemic memory in human umbilical endothelial cells.