WT1 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 12609-1-AP

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Freight/Packing

Con: 31 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human kidney tissue, A431 cells, human liver tissue, K-562 cells, MCF-7 cells, mouse kidney tissue, rat kidney tissue

Positive IP detected in:
mouse kidney tissue

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Wilms tumor 1

Calculated molecular weight:
449aa,49 kDa,57 kDa

Observed molecular weight:
52-55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
WT1

Synonyms
GUD, WAGR, Wilms tumor 1, Wilms tumor protein, WIT 2, WT1, WT33
Background

The WT1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context, and it is required for normal formation of the genitourinary system and mesothelial tissues. WT1 inhibits apoptosis through p53 and Bcl-2 and also inhibits the differentiation of leukemic cells. Function of WT1 may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.


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