|Positive WB detected in
|HEK-293 cells, HeLa cells
|Positive IP detected in
|Western Blot (WB)
|WB : 1:2000-1:12000
|IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
16820-1-AP targets ZC3HAV1 in WB, RIP, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|human, mouse, rat
|human, mouse, monkey
|Host / Isotype
|Rabbit / IgG
|ZC3HAV1 fusion protein Ag10364
|zinc finger CCCH-type, antiviral 1
|Calculated molecular weight
|699aa,78 kDa; 902aa,101 kDa
|Observed molecular weight
|GenBank accession number
|Gene ID (NCBI)
|Antigen affinity purification
|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
|Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
The zinc-finger antiviral protein (ZAP) was originally identifed from a rat cDNA library due to its conferring resistance to retroviruses. ZC3HAV1 is a CCCH-type zinc finger protein, it may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms. ZC3HAV1 exists some isoforms with MV 101, 77, 67, 42 and 18 kDa.
CG dinucleotide suppression enables antiviral defence targeting non-self RNA.
SCAF4 and SCAF8, mRNA Anti-Terminator Proteins.
Cell Host Microbe
HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization.
Rational attenuation of RNA viruses with zinc finger antiviral protein
The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting.
Nucleic Acids Res
Comprehensive analysis of the BC200 ribonucleoprotein reveals a reciprocal regulatory function with CSDE1/UNR.
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Daniel (Verified Customer) (10-26-2022)
This is a fantastic antibody. It works very reliably at high dilutions.