- Featured Product
- KD/KO Validated
ZC3HAV1 Polyclonal Antibody for IHC, IP, WB, ELISA
Cat no : 16820-1-AP
FLB6421, ZAP, ZC3H2, ZC3HAV1, ZC3HDC2, Zinc finger antiviral protein
|Positive WB detected in||HEK-293 cells, HeLa cells|
|Positive IP detected in||HeLa cells|
|Positive IHC detected in||human testis tissue, human kidney tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:1000-1:8000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:1000-1:4000 for WB|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
The 16820-1-AP immunogen is Fusion Protein ZC3HAV1 protein expressed in E. coli.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||ZC3HAV1 fusion protein Ag10364|
|Full Name||zinc finger CCCH-type, antiviral 1|
|Calculated molecular weight||699aa,78 kDa;902aa,101 kDa|
|Observed molecular weight||100 kDa|
|GenBank accession number||BC025308|
|Gene ID (NCBI)||56829|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.1% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
The zinc-finger antiviral protein (ZAP) was originally identifed from a rat cDNA library due to its conferring resistance to retroviruses. ZC3HAV1 is a CCCH-type zinc finger protein, it may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms. ZC3HAV1 exists some isoforms with MV 101, 77, 67, 42 and 18 kDa.
ZAP, a CCCH-Type Zinc Finger Protein inhibits PRRSV replication and interacts with viral Nsp9.
Zinc finger antiviral protein inhibits coxsackievirus B3 virus replication and protects against viral myocarditis.
CpG-Recoding in Zika Virus Genome Causes Host-Age-Dependent Attenuation of Infection With Protection Against Lethal Heterologous Challenge in Mice.
Inhibition of Japanese encephalitis virus infection by the host zinc-finger antiviral protein.
RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination.
Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein.