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  • KD/KO Validated

ZC3HAV1 Polyclonal antibody

ZC3HAV1 Polyclonal Antibody for IHC, IP, WB,ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat and More (1)





Cat no : 16820-1-AP


FLB6421, ZAP, ZC3H2, ZC3HAV1, ZC3HDC2, Zinc finger antiviral protein

Tested Applications

Positive WB detected inHEK-293 cells, HeLa cells
Positive IP detected inHeLa cells
Positive IHC detected inhuman testis tissue, human kidney tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:1000-1:8000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for IP and 1:1000-1:4000 for WB
Immunohistochemistry (IHC)IHC : 1:20-1:200
Sample-dependent, check data in validation data gallery

Product Information

The immunogen of 16820-1-AP is ZC3HAV1 Fusion Protein expressed in E. coli.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, monkey
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen ZC3HAV1 fusion protein Ag10364
Full Name zinc finger CCCH-type, antiviral 1
Calculated molecular weight699aa,78 kDa; 902aa,101 kDa
Observed molecular weight 100 kDa
GenBank accession numberBC025308
Gene symbol ZC3HAV1
Gene ID (NCBI) 56829
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

The zinc-finger antiviral protein (ZAP) was originally identifed from a rat cDNA library due to its conferring resistance to retroviruses. ZC3HAV1 is a CCCH-type zinc finger protein, it may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms. ZC3HAV1 exists some isoforms with MV 101, 77, 67, 42 and 18 kDa.


Product Specific Protocols
WB protocol for ZC3HAV1 antibody 16820-1-APDownload protocol
IHC protocol for ZC3HAV1 antibody 16820-1-APDownload protocol
IP protocol for ZC3HAV1 antibody 16820-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



J Virol

ZAP, a CCCH-Type Zinc Finger Protein inhibits PRRSV replication and interacts with viral Nsp9.

Authors - Yongxiang Zhao
  • KD Validated


The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts.

Authors - Ana Cristina Gonzalez-Perez

Vet Microbiol

Porcine reproductive and respiratory syndrome virus Nsp4 cleaves ZAP to antagonize its antiviral activity.

Authors - Yongxiang Zhao
human, mouseWB, IHC, IF

Antiviral Res

Zinc finger antiviral protein inhibits coxsackievirus B3 virus replication and protects against viral myocarditis.

Authors - Min Li

Front Mol Biosci

Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma.

Authors - Jian Zhang

Front Microbiol

Zinc Finger CCCH-Type Antiviral Protein 1 Restricts the Viral Replication by Positively Regulating Type I Interferon Response.

Authors - Baoge Zhang
  • KD Validated