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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human EPO

Activity

Typically ≤ 2.5 ng/mL EC50

Species Reactivity

Human

Purity

>95%

Cat no : HZ-1168

Synonyms

EP, EPO, Epoetin, erythropoietin, MVCD2



Technical Specifications

GeneID 2056
Species Human
Expression HEK293
Activity Typically ≤ 2.5 ng/mL EC50
Purity >95%
Molecular Mass 36 kDa, monomer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile I xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Product Description

Animal-free Recombinant Human EPO is expressed in human 293 cells in a serum-free, chemically defined media. EPO has more abundant and diverse glycan profiles and exhibits a lower molecular mass and substantially higher content of neutral glycans than the CHO cell produced version. See “EPO Authentic Glycan Structure” article for more information on the comparison of glycan structure.

Background

Erythropoietin (Epo) is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Epo is found in the plasma and regulates erythrocyte production by promoting erythroid differentiation and initiating hemoglobin synthesis through activation of its cognate receptor (PMID 29458727). Epo also has neuroprotective activity against a variety of potential brain injuries and anti-apoptotic functions in several tissue types (PMID 11854521).

Synonyms

EP, EPO, Epoetin, erythropoietin, MVCD2

Publications

SpeciesTitle
mouse

J Labelled Comp Radiopharm

99m Tc-labeled rHuEpo for imaging of the erythropoietin receptor in tumors.

Authors - XiaoqingZhuang
mouse

Artif Cells Nanomed Biotechnol

EPO could be regulated by HIF-1 and promote osteogenesis and accelerate bone repair.

Authors - Yijun Yu
human

Stem Cells

Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines.

Authors - Niels-BjarneWoods