|Activity||0.009-0.05 ng/mL EC50|
|Molecular Mass||21 to 25 kDa, monomer, glycosylated|
|Formulation||1x PBS, See Certificate of Analysis for details|
Stability and Reconstitution
|Stability and Storage||Product Form||Temperature Conditions||Storage Time|
(From Date of Receipt)
|Lyophilized||-20°C to -80°C||Until Expiry Date|
|Lyophilized||Room Temperature||2 weeks|
|Reconstituted as per CofA||-20°C to -80°C||6 months|
|Reconstituted as per CofA||4°C||1 week|
|Avoid repeated freeze-thaw cycles.|
|Reconstitution||Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).|
Granulocyte colony-stimulating factor (G-CSF), also known as CSF3, is a protective cytokine with anti-inflammatory effects. G-CSF is important in promoting survival of the granulocytic lineage cells and proliferation and migration of neutrophils and trophoblast cells. G-CSF exerts its effects by binding to its receptor G-CSFR, in turn activating the JAK/STAT and Ras/Raf/MAP kinase pathways (PMID 9015216, 7509213, 9933603). G-CSF potently stimulates the proliferation and release of peripheral blood progenitor cells into the bloodstream and is therefore used to treat neutropenia after chemotherapy (PMID 7524753, 3264199). Furthermore, G-CSF levels are elevated upon intensive exercise leading to increased neutrophil counts, which are predominantly due to delayed neutrophil apoptosis (PMID 18524991).
C17orf33, CSF3, Filgrastim, G CSF, GCSF, G-CSF, Lenograstim, Pluripoietin
Breast Cancer Res Treat
A high-risk luminal A dominant breast cancer subtype with increased mobility.
J Toxicol Environ Health A
The protective mechanisms underlying Ginsenoside Rg1 effects on rat sciatic nerve injury.
J Mol Cell Biol
Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage.
Evaluation of the Effects of Exposure to Power-Frequency Magnetic Fields on the Differentiation of Hematopoietic Stem/Progenitor Cells Using Human-Induced Pluripotent Stem Cells.
HIV-1 Tat Protein Induces Production of Proinflammatory Cytokines by Human Dendritic Cells and Monocytes/Macrophages through Engagement of TLR4-MD2-CD14 Complex and Activation of NF-κB Pathway.
J Cell Mol Med
M2 macrophage-derived G-CSF promotes trophoblasts EMT, invasion and migration via activating PI3K/Akt/Erk1/2 pathway to mediate normal pregnancy.