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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human IL-1 beta


Typically ≤ 0.05 ng/mL EC50

Species Reactivity




Cat no : HZ-1164


Catabolin, IL 1, IL 1 beta, IL1 BETA, IL-1 beta, IL1B, IL-1b, IL1beta, IL1F2, Interleukin 1 beta, interleukin 1, beta

Technical Specifications

GeneID 3553
Species human
Expression HEK293
Activity Typically ≤ 0.05 ng/mL EC50
Purity >95%
Molecular Mass 18 and 25 kDa, monomer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human, mouse

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Product Description

Animal-free Recombinant Human IL-1 beta expressed in human 293 cells has a very high activity with a typical EC50 of ≤0.1 ng/mL using a bioassay to measure stimulation of the proliferation of mouse D10S cells. In comparison with the E. coli expressed protein, IL-1 beta is 50% more potent promoting human CD4+ T cell differentiation into Th17 cells. This cytokine is important for inflammatory responses. It is also involved in a variety of cellular activities which includes cell differentiation, proliferation, and apoptosis. It is produced in a serum-free, chemically defined media.


Catabolin, IL 1, IL 1 beta, IL1 BETA, IL-1 beta, IL1B, IL-1b, IL1beta, IL1F2, Interleukin 1 beta, interleukin 1, beta



Mediators Inflamm

Matrix Metalloproteinase-9-Dependent Release of IL-1β by Human Eosinophils.

Authors - Stephane Esnault

Biosci Trends

Analysis of cytotoxicity induced by proinflammatory cytokines in the human alveolar epithelial cell line A549.

Authors - MitsuakiMuroya

BMC Musculoskelet Disord

Effect of interleukin-1β treatment on co-cultures of human meniscus cells and bone marrow mesenchymal stromal cells.

Authors - AnikaChowdhury

Life Sci

Cynaropicrin is dual regulator for both degradation factors and synthesis factors in the cartilage metabolism.

Authors - TeruakiMasutani

Int Immunopharmacol

Autonomous cure of damaged human intestinal epithelial cells by TLR2 and TLR4-dependent production of IL-22 in response to Spirulina polysaccharides.

Authors - AkiraTominaga

PLoS One

Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2, TGF-β and retinoic acid.

Authors - LingLu