Alpha-2-macroglobulin Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66126-1-Ig |CloneNo.: 4B11F7

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Freight/Packing

Con: 270 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HepG2 cells, human brain tissue

Positive IP detected in:
human plasma tissue

Positive IHC detected in:
human liver tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
alpha-2-macroglobulin

Calculated molecular weight:
1474aa,163 kDa

Observed molecular weight:
185 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
A2M

Synonyms
A2M, Alpha 2 M, alpha 2 macroglobulin, CPAMD5, DKFZp779B086, FWP007, S863 7, α-2M
Background

alpha-2-macroglobulin, also known as α2-macroglobulin (α2M and A2M), is a protein abundant in the plasma of vertebrates and several invertebrates. A2M is an evolutionarily conserved arm of the innate immune system. It also mediates the proliferation of T cells and macrophages. A2M acts as a nonspecific protease inhibitor involved in the host defense mechanism that inactivates both endogenous and exogenous proteases, including trypsin, thrombin and collagenase. Even though A2M is produced predominantly by the liver, it may also be expressed in the reproductive tract, heart, and brain, and may have important roles in many physiological processes and medical illnesses including Alzheimer’s disease.


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