P glycoprotein Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 22336-1-AP

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Freight/Packing

Con: 72 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HepG2 cells

Positive IP detected in:
human placenta tissue

Positive IHC detected in:
human liver cancer tissue, human liver cancer tissue, mouse kidney tissue

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ATP-binding cassette, sub-family B (MDR/TAP), member 1

Calculated molecular weight:
1280aa,142 kDa

Observed molecular weight:
130-150 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ABCB1

Synonyms
ABCB1, CD243, GP170, MDR1, Multidrug resistance protein 1, P glycoprotein 1
Background

ABCB1 (also known as P-gp/ P-glycoprotein, MDR1/multidrug-resistance 1) is a plasma membrane protein first discovered in multidrug resistant tumor cells. ABCB1 can extrude a large number of medically relevant compounds from cells and causes drug resistance. ABCB1 is expressed in a variety of human cancers as well as normal tissues including brain, and placenta. Overexpression of ABCB1 correlates with a negative prognosis in several types of cancer.


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