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ACE2 contains a potential 17-amino acid N-terminal signal peptide and a putative 22-amino acid C-terminal membrane anchor. It is the only known mammalian homologue of the zinc-metallopeptidase angiotensin-converting enzyme (ACE), a critical regulator of the reninangiotensin system.ACE2 has a more restricted tissue distribution than ACE, being found predominantly in the heart, kidneys, and testes although low levels have been detected in a variety of tissues(PMID:15983030). It can be N-Deglycosylation(PMID:16166094).It has 2 isoforms produced by alternative splicing.This antibody is specific to ACE2.