ACVRL1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 14745-1-AP

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Freight/Packing

Con: 29 μg/150 μl

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Species specificity:
human

Positive WB detected in:
human placenta tissue

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human heart tissue, human heart tissue, human lymphoma tissue

Positive FC detected in:
Jurkat cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
activin A receptor type II-like 1

Calculated molecular weight:
56 kDa

Observed molecular weight:
63 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ACVRL1

Synonyms
Activin receptor like kinase 1, ACVRL1, ACVRLK1, ALK 1, ALK1, HHT, HHT2, ORW2, SKR3, TSR I
Background

ACVRL1 (also known as ALK1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1 is highly expressed in endothelial cells and has a critical role in the control of blood vessel development and repair (PMID: 8640225). Mutations in the ACVRL1 gene are associated with hemorrhagic telangiectasia type 2.


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