AP2S1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 15634-1-AP

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Freight/Packing

Con: 20 μg/150 μl

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Tested Applications

Applications:
ELISA
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Species specificity:
human, mouse, rat

Recommended dilution:

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
adaptor-related protein complex 2, sigma 1 subunit

Calculated molecular weight:
142aa,17 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AP2S1

Synonyms
AP 2 complex subunit sigma, AP17, AP17 DELTA, AP2S1, CLAPS2, HA2 17 kDa subunit, Sigma2 adaptin
Background

AP2S1 is a component of the adaptor protein complex 2 (AP-2). AP complexes are cytosolic heterotetramers that mediate the sorting of membrane proteins in the secretory and endocytic pathways. AP complexes are involved in the formation of clathrin-coated vesicles (CCVs) by recruiting the scaffold protein, clathrin. AP complexes also play a pivotal role in the cargo selection by recognizing the sorting signals within the cytoplasmic tail of integral membrane proteins. AP-2 is composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). It works on the plasma membrane to internalize cargo in clathrin-mediated endocytosis.


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