ATF4 Antibody 61 Publications

Rabbit Polyclonal| Catalog number: 10835-1-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 40 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat, pig

Positive WB detected in:
A431 cells, DU 145 cells, HEK-293 cells, mouse kidney tissue, rat brain tissue, SGC-7901 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human breast cancer tissue

Positive FC detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
activating transcription factor 4 (tax-responsive enhancer element B67)

Calculated molecular weight:
39 kDa

Observed molecular weight:
50-58 kDa, 35-38 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ATF4

Synonyms
ATF4, CREB 2, CREB2, DNA binding protein TAXREB67, TAXREB67, TXREB
Background

ATF4 is a transcription factor, that accumulates predominantly in osteoblasts, where it regulates terminal osteoblast differentiation and bone formation[PMID: 19016586]. As a basic leucine-zipper (bZip) transcription factor, ATF4 can regulate amino acid metabolism, cellular redox state, and anti-stress responses. It also regulates age-related and diet-induced obesity and glucose homeostasis in mammals, and has conserved metabolic functions in flies[PMID: 19726872]. Due to its location at chromosome 22q13, a region linked to schizophrenia, ATF4 is considered as a positional candidate gene for schizophrenia[PMID: 18163433]. Otherwise, since ATF4 is induced by tumour microenvironmental factors, and regulates processes relevant to cancer progression, it might serve as a potential therapeutic target in cancer. Endogenous ATF4 protein has a molecular mass of 50kd. [PMID: 17726049]. This antibody is a rabbit polyclonal antibody raised against full length human ATF4 antigen. The antibody recognizes the 38kd ATF4 protein and its phosphorylated forms (50kd).


Back
to top