BIN2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 14245-1-AP

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Con: 30 μg/150 μl

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Species specificity:
human

Positive WB detected in:
U-937 cells, Jurkat cells

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human spleen tissue, human heart tissue, human lung tissue, human ovary tissue, human skin tissue, human spleen tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
bridging integrator 2

Calculated molecular weight:
62 kDa

Observed molecular weight:
80-90 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BIN2

Synonyms
BIN2, BRAP 1, BRAP1, bridging integrator 2
Background

BAR proteins, which are characterized by a common N-terminal BAR domain, are a family of adaptor proteins implicated in a diverse set of cellular processes. BIN1 (bridging integrator 1) and BIN2 are BAR proteins. The human BIN2 gene is located at chromosome 4q22.1, and encodes a 565-amino acid protein with a predicted molecular weight of ~62 kDa. It shows preferential expression in hematopoietic tissues, with highest mRNA levels in spleen and peripheral blood leukocytes and also high levels in thymus, colon, and placenta. BIN2 has been shown to migrate with an apparent mobility of ~80 kDa, and interact with BIN1. (PMID: 10903846)


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