NeutraKine® BMP-7 Monoclonal antibody

NeutraKine® BMP-7 Monoclonal Antibody for FC (Intra), Neutralization, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse

Applications

Neutralization, FC (Intra), ELISA

Conjugate

Unconjugated

CloneNo.

3E9G7

Cat no : 69011-1-Ig

Synonyms

BMP 7, BMP7, BMP-7, bone morphogenetic protein 7, Eptotermin alfa, NeutraKine® BMP-7, OP 1, OP1, Osteogenic protein 1



Neutralization

Product Information

69011-1-Ig targets NeutraKine® BMP-7 in Neutralization, FC (Intra), ELISA applications and shows reactivity with Human, mouse samples.

Tested Reactivity Human, mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen human Humankine BMP-7 protein HZ-1229
Full Name bone morphogenetic protein 7
Gene Symbol BMP7
Gene ID (NCBI) 655
RRIDAB_2882929
Conjugate Unconjugated
Form Lyophilized Powder
Purification MethodProtein G purification
Storage Buffer Sterile PBS.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Background Information

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.

BMP7, also known as osteogenic protein-1 or OP-1, plays a key role in the transformation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis (PMID: 15621726). It is expressed in the brain, kidneys and bladder. BMP7 is also present in cancers, including breast, prostate, and colon cancers, in which it is implicated in regulating cancer cell proliferation (PMID: 16419056, PMID: 15531927). Overexpression of BMP7 mRNA in colorectal cancer patients was significantly associated with poor prognosis and low overall survival (PMID: 18259822). Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC (PMID: 23179403).

This antibody can be used to neutralize the bioactivity of BMP-7.