CoraLite®647-conjugated BMP-7 Monoclonal antibody
BMP-7 Monoclonal Antibody for FC
Host / Isotype
Mouse / IgG1
CoraLite®647 Fluorescent Dye
Cat no : CL647-69011
|Positive FC detected in||HEK-293 cells|
|Sample-dependent, check data in validation data gallery|
CL647-69011 targets BMP-7 in FC applications and shows reactivity with Human samples.
|Host / Isotype||Mouse / IgG1|
|Immunogen||BMP-7 fusion protein HZ-1229|
|Full Name||bone morphogenetic protein 7|
|Gene ID (NCBI)||655|
|Conjugate||CoraLite®647 Fluorescent Dye|
|Excitation/Emission maxima wavelengths||650 nm/665 nm|
|Purification Method||Protein G purification|
|Storage Buffer||PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.|
|Storage Conditions||Store at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage.|
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.
BMP7, also known as osteogenic protein-1 or OP-1, plays a key role in the transformation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis (PMID: 15621726). It is expressed in the brain, kidneys and bladder. BMP7 is also present in cancers, including breast, prostate, and colon cancers, in which it is implicated in regulating cancer cell proliferation (PMID: 16419056, PMID: 15531927). Overexpression of BMP7 mRNA in colorectal cancer patients was significantly associated with poor prognosis and low overall survival (PMID: 18259822). Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC (PMID: 23179403).
This antibody is used to Block/Neutralize BMP-7 protein.