BRAF Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 20899-1-AP

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Freight/Packing

Con: 37 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
NIH/3T3 cells,A431 cells, A375 cells

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human malignant melanoma tissue,human thyroid cancer tissue, human testis tissue

Positive IF detected in:
NIH/3T3 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:100-1:400
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
v-raf murine sarcoma viral oncogene homolog B1

Calculated molecular weight:
766aa,84 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BRAF

Synonyms
B RAF1, BRAF, BRAF1, FLJ95109, p94, Proto oncogene B Raf, RAFB1
Background

B-Raf proto-oncogene, serine/threonine kinase(BRAF). is a protein belonging to the raf/mil family of serine/threonine protein kinases.BRAF plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. BRAF is associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance.BRAF is also associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. BRAF plays a role in the PD-1/PDL-1 pathway. In some cancers, BRAF is activated by rearrangements that fuse its kinase domain to 5′ partner genes and then has different molecular weights (PMID: 23890088).


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