BubR1 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 11504-2-AP

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 37 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse

Positive WB detected in:
mouse testis tissue, HeLa cells, human testis tissue, K-562 cells

Positive IHC detected in:
human colon cancer tissue

Positive IF detected in:
SKOV-3 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:100-1:400
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
budding uninhibited by benzimidazoles 1 homolog beta (yeast)

Calculated molecular weight:
1050aa,120 kDa

Observed molecular weight:
120-130 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BUB1B

Synonyms
Bub1A, BUB1B, BUB1beta, BubR1, hBUBR1, MAD3L, Protein SSK1, SSK1
Background

BUB1B(Mitotic checkpoint serine/threonine-protein kinase BUB1 beta), also named as BUBR1, MAD3Land SSK1, belongs to the BUB1 subfamily. Human BUB1B is a 120 kDa protein that plays a central role in the spindle assembly checkpoint (SAC), the evolutionary conserved and self-regulatory system of higher organisms that monitors and repairs defects in chromosome segregation in mitotic cells(PMID:22201036). In addition to phosphorylation, BUB1B is also subjected to posttranslational modifications including acetylation(PMID:22167194). Defects in BUB1B are the cause of premature chromatid separation trait (PCS) and mosaic variegated aneuploidy syndrome type 1 (MVA1).


Back
to top