Images See all
MUC1, a type I transmembrane glycoprotein, belongs to the family of mucin proteins which are expressed by various epithelial cell types. It consists of a very large extracellular domain, a trans-membrane domain, and a short cytoplasmic tail. Among the known mucins, MUC1 is best studied and plays crucial roles in regulating many cellular properties, including cell proliferation, apoptosis, adhesion, and invasion. MUC1 primarily functions in lubrication and hydration of epithelia and protection from microbial attack. It also has been implicated in progression of numerous types of cancer.