|Positive WB detected in||mouse liver tissue, A549 cells, human placenta tissue, mouse lung tissue|
|Western Blot (WB)||WB : 1:500-1:1000|
|Sample-dependent, check data in validation data gallery|
14335-1-AP targets CADM1 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||CADM1 fusion protein Ag5621|
|Full Name||cell adhesion molecule 1|
|Calculated molecular weight||49 kDa|
|Observed molecular weight||49-60 kDa|
|GenBank accession number||BC047021|
|Gene ID (NCBI)||23705|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
CADM1 (cell adhesion molecule 1), also referred to as SgIGSF, Necl-2 or TSLC-1, is a cell adhesion molecule belonging to the immunoglobulin superfamily. It can mediate homophilic and heterophilic cell-cell adhesion. CADM1 is expressed by a variety of cells including neurons, mast cells, spermatogonia, pancreatic islet cells, epithelial cells such as lung alveolar cells and biliary epithelial cells. CADM1 is involved in carcinoma pathogenesis and the expression of CADM1 is frequently down-regulated in various tumors derived from epithelial cells. It acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. (PMID: 18332875; 17326163; 20340131)
miR-214-3p promotes the proliferation, migration and invasion of osteosarcoma cells by targeting CADM1.
Onco Targets Ther
miR-424-5p Promotes Proliferation, Migration and Invasion of Laryngeal Squamous Cell Carcinoma.
Necl-4/SynCAM-4 is expressed in myelinating oligodendrocytes but not required for axonal myelination.