CBLB Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 12781-1-AP

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Freight/Packing

Con: 41 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, A549 cells, HEK-293 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human lung cancer tissue, human kidney tissue, human lung tissue, human placenta tissue, human spleen tissue, human testis tissue, mouse colon tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Cas-Br-M (murine) ecotropic retroviral transforming sequence b

Calculated molecular weight:
982aa,109 kDa

Observed molecular weight:
109 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CBLB

Synonyms
CBLB, DKFZp686J10223, DKFZp779A0729, DKFZp779F1443, FLJ36865, FLJ41152, Nbla00127, RING finger protein 56, RNF56, SH3 binding protein CBL B
Background

CBLB(E3 ubiquitin-protein ligase CBL-B) is also named as RNF56 and plays a necessary role to prevent the inappropriate activation of NF-B in response to lipopolysaccharide and to polymicrobial sepsis. CBLB can be phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation.. It also has a crucial role in the prevention of chronic inflammation and autoimmunity. This protein has 3 isoforms produced by alternative splicing.


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