CEP290 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 22490-1-AP

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Freight/Packing

Con: 77 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human placenta tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
centrosomal protein 290kDa

Calculated molecular weight:
2479aa,290 kDa

Observed molecular weight:
290 kDa, 150-180 kDa, 80 kDa,60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CEP290

Synonyms
3H11Ag, BBS14, Cancer/testis antigen 87, centrosomal protein 290kDa, Centrosomal protein of 290 kDa, CEP290, CT87, FLJ13615, FLJ21979, JBTS5, JBTS6, KIAA0373, LCA10, MKS4, Nephrocystin 6, rd16, SLSN6, Tumor antigen se2 2
Background

Studies in the Chlamydomonas model system has shown that the ciliary protein CEP290 is a critical component of these Y-link junctions. Additionally, numerous studies have demonstrated that CEP290’s function is critical for IFT—in CEP290 knockdown experiments, many proteins that would normally localize to the cilium fail to do so, and cilium formation is disrupted or absent. Mutations in CEP290 are accountable for cases of nephronophthisis, Leber congenital amaurosis and Joubert syndrome. In IF analtsis of HeLa cells, the white arrows show centrosome and cilium staining.


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