CHMP2B Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 12527-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
SH-SY5Y cells, human brain tissue, human heart tissue, human ileum tissue, human kidney tissue, human placenta tissue, mouse brain tissue, NIH/3T3 cells

Positive IHC detected in:
human liver tissue, human brain tissue, human liver tissue

Positive IF detected in:
HepG2 cells, PFA fixed cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
chromatin modifying protein 2B

Calculated molecular weight:
24 kDa

Observed molecular weight:
32 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CHMP2B

Synonyms
CHMP2.5, CHMP2B, chromatin modifying protein 2B, DKFZp564O123, DMT1, hVps2 2, VPS2 2, VPS2B
Background

CHMP2B, chromatin-modifying protein 2b, also named as CHMP2.5, VPS2B and VPS2 2, belongs to the chromatin-modifying protein / charged multivesicular body protein (CHMP) family. It is a component of endosomal sorting complex required for transport III (ESCRT-III), which involves in endosomal and autophagic trafficking of proteins to lysosomes for degradation. Mutations of CHMP2B lead to C-terminal truncation or been replaced with mis-splicing C-termini and cause frontotemporal lobar degeneration (FTLD). In CHMP2B mutation patients, p62- and ubiquitin-positive, but TDP-43 and FUS negative neural inclusions are formed, maybe caused by impaired lysosomal degradation through the autophagy and endosome-lysosome pathways.


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