CISD2-Specific Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66082-1-Ig |CloneNo.: 3D7A3

Featured Product KD/KO validated

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Freight/Packing

Con: 248 μg/150 μl

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Species specificity:
human, zebrafish, rat, mouse

Positive WB detected in:
fetal human brain tissue,MCF-7 cells, HeLa cells, ROS1728 cells, RAW 264.7 cells, zebrafish tissue

Positive IHC detected in:
human kidney tissue, human kidney tissue, human testis tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:2000-1:16000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Fusion Protein

Full name:
CDGSH iron sulfur domain 2

Calculated molecular weight:

Observed molecular weight:
15 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CISD2

Synonyms
CDGSH iron sulfur domain 2, CDGSH2, CISD2, CISD2-Specific, ERIS, Miner1, MitoNEET related 1 protein, NAF 1, WFS2, ZCD2
Background

CISD2 gene encodes a 15 kDa CDGSH iron-sulfur domain-containing protein 2, which is also named Miner1 or NAF-1, this protein was reported on endoplasmic reticulum membrane or mitochondrion outer membrane. Defects in CISD2 are the cause of Wolfram syndrome type 2 (WFS2), a rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. CISD2 regulates autophagy program by interacting BCL2, contributing to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. This monoclonal antibody is specific to CISD2 and does not cross-react with CISD1.


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