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CLP1 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 14746-1-AP

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Con: 64 μg/150 μl

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Tested Applications

Applications:
WB, ELISA
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CLP1 Antibody WB HeLa cells 14746-1-AP

HeLa cells were subjected to SDS PAGE followed by western blot with 14746-1-AP( CLP1 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours

Species specificity:
human, mouse
Positive WB detected in:
HeLa cells, mouse testis tissue
Recommended dilution:
WB : 1:200-1:1000

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
CLP1 fusion protein Ag6479
Full name:
CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)
Calculated molecular weight:
48 kDa
Observed molecular weight:
41, 48 kDa
GenBank accession number:
BC000446
Gene ID (NCBI):
10978
Gene symbol
CLP1
Synonyms
CLP1, hClp1, HEAB, Polynucleotide kinase Clp1

Background

CLP1, also named as HEAB, is a 425 amino acid protein, which belongs to the Clp1 family. CLP1 as a polynucleotide kinase, that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. Human CLP1 is a component of the mRNA 3’end cleavage and polyadenylation machinery4,5 and studies in yeast have postulated a function for CLP1 in coupling mRNA 3’ end processing with RNA Pol II transcriptional termination. CLP1 exists 2 isoforms with MV 41 kDa and 48 kDa.


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