Collagen Type VI Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 14853-1-AP

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Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human heart tissue

Positive IHC detected in:
human heart tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
collagen, type VI, alpha 2

Calculated molecular weight:
109 kDa

Observed molecular weight:
140 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
COL6A2

Synonyms
COL6A2, Collagen alpha 2(VI) chain, Collagen Type VI, collagen, type VI, alpha 2, DKFZp586E1322, FLJ46862, PP3610
Background

Collagen VI, composed of three polypeptides, alpha-1(VI), alpha-2(VI), and alpha-3(VI) chains, is a beaded filament collagen found in most connective tissues. The alpha-1(VI) and alpha-2(VI) chains are 140 kDa, while the alpha-3(VI) chain is 200-300 kDa (PMID: 3792302, 3348212). COL6A2 gene encodes the alpha-2 subunit of type VI collagen. The alpha-2(VI) subunit has a calculated molecular weight of 109 kDa, and an apparent molecular weight of 140 kDa due to posttranslational modification. Mutations in COL6A2 gene are associated with Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. Three transcript variants have been identified for this gene.


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