Cathepsin D Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 21327-1-AP

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Freight/Packing

Con: 37 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
MCF7 cells, A431 cells, HepG2 cells, HT-1080 cells, L02 cells

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human hepatocirrhosis tissue, human liver cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:100-1:400
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cathepsin D

Calculated molecular weight:
412aa,45 kDa

Observed molecular weight:
48-52 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CTSD

Synonyms
cathepsin D, CLN10, CPSD, CTSD
Background

CTSD(Cathepsin D) is also named as CPSD,belongs to the peptidase A1 family.It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. The prepro-CTSD isoform has a molecular mass of 52 kDa, the pro-CTSD 48 kDa and the mature CTSD 32 kDa(PMID:10917609). It is a lysosomal acid protease found in neutrophils and monocytes and involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10).This antibody is specific to CTSD.


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