Cathepsin K Antibody 13 Publications

Rabbit Polyclonal| Catalog number: 11239-1-AP

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Freight/Packing

Con: 55 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
ROS1728 cells, mouse uterus tissue

Positive IP detected in:
ROS1728 cells

Positive IHC detected in:
human breast cancer tissue, human lung cancer tissue, human osteosarcoma tissue

Positive IF detected in:
ROS1728 cells, HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:100-1:400
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cathepsin K

Calculated molecular weight:
39 kDa

Observed molecular weight:
29-36 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CTSK

Synonyms
Cathepsin K, Cathepsin O, Cathepsin O2, Cathepsin X, CTS02, CTSK, CTSO, CTSO1, CTSO2, PKND, PYCD
Background

CTSK(cathepsin K), also named as CTSO, CTSO2, is a recently identified lysosomal cysteine proteinase. CTSK is synthesized as a proenzyme of 38 kDa and subsequently enters acidic lysosomal compartments, in which the propeptide is cleaved and transformed into an active enzyme and it may influence adipocyte differentiation through modifying extracellular matrix components(PMID:16912123). It is revealed both the 46-kDa cathepsin-K precursor and the 30-kDa mature form in mouse bone extracts(PMID:9811821). The high CTSK protein levels are only detected in primary cultured fibroblasts derived from normal and neoplastic breast tissue, where the 37- and 25-kDa bands to be detected correspond to pro- and mature proteins through western blot(PMID:18765527). The full length protein has a signal peptides with 15 amino acids and a propeptide with 99 amino acids. CTSK may have cross reaction with the other members of cathepsin family and form a complex of 70 kDa with an unidentified subunit(PMID:1930136).


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