Cortactin Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 11381-1-AP

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Freight/Packing

Con: 65 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, HEK-293 cells, MCF-7 cells, NIH/3T3 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human pancreas cancer tissue

Positive IF detected in:
HeLa cells, HepG2 cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cortactin

Calculated molecular weight:
57 kDa

Observed molecular weight:
75~80 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CTTN

Synonyms
Amplaxin, cortactin, CTTN, EMS1, Oncogene EMS1, Src substrate cortactin
Background

Cortactin, encoded by CTTN gene (formerly EMS1), was originally identified as a substrate of the Src kinase. It is a cytoskeletal protein that interacts with F-actin and Arp2/3 complex and plays an important role in regulation of actin assembly and cytoskeleton dynamics. Overexpression of cortactin increases cell migration, and is thought to contribute to the invasive phennotype of breast cancer and several other tumors. Three isoforms of cortactin exist due to the alternative splicing. Although cortactin has a predicted molecular weight around 65 kDa, it has 3 isoforms with MW of 57-70 kDa and migrates as multiple bands between 75 and 85 kDa in SDS-PAGE.


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