CXCL13/BCA1 Polyclonal Antibody for IHC, WB, ELISA
Cat no : 10927-1-AP
ANGIE, ANGIE2, B cell attracting chemokine 1, B lymphocyte chemoattractant, BLC, BLR1L, C X C motif chemokine 13, CXC chemokine BLC, CXCL13, SCYB13, Small inducible cytokine B13
|Positive WB detected in||human placenta tissue, human plasma tissue, Jurkat cells|
|Positive IHC detected in||human tonsillitis tissue, human renal cell carcinoma tissue, human breast cancer tissue, human lymphoma tissue, human liver tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:1000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
10927-1-AP targets CXCL13/BCA1 in WB, IHC, IF, ELISA applications and shows reactivity with human samples.
|Host / Isotype||Rabbit / IgG|
|Immunogen||CXCL13/BCA1 fusion protein Ag1358|
|Full Name||chemokine (C-X-C motif) ligand 13|
|Calculated molecular weight||13 kDa|
|Observed molecular weight||10 kDa|
|GenBank accession number||BC012589|
|Gene ID (NCBI)||10563|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.1% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
BLR1 (Burkitt lymphoma receptor-1), also called CXCR5, is highly expressed on Burkitt lymphoma cells and B lymphocytes. It may therefore function in the homing of B lymphocytes to follicles. It was reported that the B cell chemokine CXCL13 is elevated in MS serum and cerebrospinal fluid. CXCL13 is also regarded as a proposed serum biomarker of synovitis in RA( Rheumatoid arthritis). CXCL13 consists of a 22-aa signal peptide and a 87-aa mature poly-peptide.
The role of high serum CXCL13 level in Waldenström macroglobulinemia.
Defined lifestyle and germline factors predispose Asian populations to gastric cancer.
J Matern Fetal Neonatal Med
A role for CXCL13 (BCA-1) in pregnancy and intra-amniotic infection/inflammation.
Mol Med Rep
MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis.
Identification of CXCL13 as a potential biomarker in clear cell renal cell carcinoma via comprehensive bioinformatics analysis.
Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease.