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- KD/KO Validated
CXCR3B-specific Monoclonal antibody
CXCR3B-specific Monoclonal Antibody for FC, IHC, WB,ELISA
Cat no : 60065-1-Ig
|Positive WB detected in||Hela cells, U-937 cells, Jurkat cells|
|Positive IHC detected in||human tonsillitis tissue, human liver cancer tissue, human brain tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive FC detected in||U-937 cells|
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
60065-1-Ig targets CXCR3B-specific in WB, IHC, IF, FC,ELISA applications and shows reactivity with human samples.
|Host / Isotype||Mouse / IgG2b|
|Full Name||chemokine (C-X-C motif) receptor 3|
|Calculated molecular weight||46 kDa|
|Observed molecular weight||40 kDa+43 kDa|
|GenBank accession number||AF469635|
|Gene ID (NCBI)||2833|
|Purification Method||Caprylic acid/ammonium sulfate precipitation|
|Storage Buffer||PBS with 0.1% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
CXCR3 (C-X-C chemokine receptor type 3) is a G protein-coupled, seven-transmembrane domain chemokine receptor that is expressed on the surface of a number of cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells (PMID: 16847335). CXCR3 binds and is activated by the three IFN-gamma-inducible chemokines: CXCL9, CXCL10, and CXCL11. Binding of these ligands to CXCR3 has been implicated in regulating T-cell infiltration during inflammation and tissue injury (PMID: 17250586). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms, CXCR3B, mediates the angiostatic activity of CXCR3 ligands and also acts as functional receptor for CXCL4 (PMID:12782716). This monoclonal antibody is specific to CXCR3B.
Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo.
Breast Cancer (Auckl)
The Chemokine Receptor CXCR3 Isoform B Drives Breast Cancer Stem Cells.
Wound Repair Regen
Differential Regulation of Pericyte Function by the CXC Receptor 3.
Overexpression of the chemokine receptor CXCR3 and its correlation with favorable prognosis in gastric cancer.
CXCL11 promotes tumor progression by the biased use of the chemokine receptors CXCR3 and CXCR7.
CXCL12-CXCL4 heterodimerization prevents CXCL12-driven breast cancer cell migration.