CYP17A1 Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 14447-1-AP

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Freight/Packing

Con: 43 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HeLa cells,Jurkat cells, A549 cells, rat brain tissue, HepG2 cells, mouse brain tissue

Positive IHC detected in:
human prostate cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:100-1:400
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cytochrome P450, family 17, subfamily A, polypeptide 1

Calculated molecular weight:
57 kDa

Observed molecular weight:
48-51 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CYP17A1

Synonyms
CPT7, CYP17, CYP17A1, CYPXVII, Cytochrome P450 17A1, Cytochrome P450 C17, Cytochrome P450c17, P450C17, S17AH, Steroid 17 alpha monooxygenase
Background

The human cytochrome P450c17 enzyme is encoded by the CYP17A1 gene. It is the qualitative regulator of steroidogenesis in the human adrenals.In its absence, aldosterone is produced in the human adrenal zona glomerulosa .The CYP17A1 gene is expressed in the adrenal cortex and the gonads but not in the placenta (PMID;19403566). Although CYP17A1 has been shown to be a 50-kDa protein, the presence of a lower molecular mass(30 kDa) immunoreactive form in rat Ley- dig cells was previously shown and it is either a degradation product or a truncated form of the 50 kDa enzyme(PMID:15761033). Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5).


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