CYP26B1 Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 21555-1-AP

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Freight/Packing

Con: 31 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, L02 cells

Positive IP detected in:
L02 cells

Positive IHC detected in:
human hepatocirrhosis tissue, human heart tissue, human hepatocirrhosis tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cytochrome P450, family 26, subfamily B, polypeptide 1

Calculated molecular weight:
512aa,58 kDa

Observed molecular weight:
58-60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CYP26B1

Synonyms
CYP26A2, CYP26B1, Cytochrome P450 26A2, Cytochrome P450 26B1, Cytochrome P450RAI 2, DKFZp686G0638, P450RAI 2, P450RAI2
Background

CYP26B1(Cytochrome P450 26B1) is involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation.It has 3 isoforms produced by alternative splicing.Cyp26b1 deficiency induces pronounced apoptosis in the developing limb and delayed chondrocyte maturation(PMID:15030763).Defects in CYP26B1 are the cause of radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA).


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