DDX3 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 11115-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 36 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse liver tissue, C6 cells, HeLa cells, HepG2 cells, HT-1080 cells, NIH/3T3 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human cervical cancer tissue

Positive IF detected in:
Ethacrynic acid treated HepG2 cells, HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked

Calculated molecular weight:
73 kDa

Observed molecular weight:
73 kDa, 60-65 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DDX3X

Synonyms
DBX, DDX14, DDX3, DDX3X, DEAD box, X isoform, Helicase like protein 2, HLP2
Background

DDX3X, also named as DBX, DDX3 and HLP2, belongs to the DEAD box helicase family and DDX3/DED1 subfamily. It is ATP-dependent RNA helicase. DDX3X acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. It is also involved in HIV-1 replication. DDX3X interacts specifically with hepatitis C virus core protein resulting in a change in intracellular location. 73kd is the target band. 60-65kd is some other isoform. This antibody can bind both DDX3X and DDX3Y for the close sequences.


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