DGCR8 C-terminal Antibody 51 Publications

Rabbit Polyclonal| Catalog number: 10996-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 28 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, A431 cells, HEK-293 cells, HeLa cells, mouse testis tissue

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human breast cancer tissue, human colon cancer tissue

Positive IF detected in:
SH-SY5Y cells

Positive FC detected in:
HeLa cells, SH-SY5Y cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
DiGeorge syndrome critical region gene 8

Calculated molecular weight:
773aa,86 kDa

Observed molecular weight:
120 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DGCR8

Synonyms
C22orf12, DGCR8, DGCRK6, Gy1
Background

DGCR8 is a RNA-binding protein that assists the Rnase III enzyme Drosha in the processing of microRNAs (miRNAs), which regulate the expression of a large number of protein-coding genes[PMID: 22580560]. DGCR8, which contains two double-stranded RNA (dsRNA)-binding domains, may be an essential component of the primary miRNAs processing complex, along with Drosha, promoting the processing of primary microRNA to precursor microRNA. It is ubiquitous expressed in human and mouse tissues, and is deleted in DiGeorge syndrome[22323604]. The calculated molecular weight of DGCR8 is 82-86 kDa, but the post-modified DGCR8 is about 120 kDa (PMID: 18469815).


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