DNASE1L3 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 11330-1-AP

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 20 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
deoxyribonuclease I-like 3

Calculated molecular weight:
305aa,36 kDa

Observed molecular weight:
33kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DNASE1L3

Synonyms
DNASE1L3, DNase gamma, DNAS1L3, DNase I like 3, DNase I homolog protein DHP2
Background

Deoxyribonuclease 1-like 3 (DNASE1L3, DNase gamma, DNase Y, LS-DNase) is member of a DNASE1 protein family that is identified by similar biochemical properties such as Ca2+/Mg2+- dependency and an optimal pH of about 7.0 as well as by a high similarity in their nucleic acid and amino acid sequences [PMID:15796714]. It is an endonuclease and cleaves double-stranded DNA (and single-stranded DNA) producing 3′-OH/5′-P ends, which is Ca2+/Mg2+-dependent and inhibited by Zn2+, but not by monomeric actin [PMID:9665719]. In addition, it has been suggested to be involved in apoptotic DNA fragmentation of thymocytes' neuronal PC12 cells, C2C12 myoblasts and of cell lines expressing the recombinant nuclease [PMID: 7957253, 9307016]


Back
to top