DVL2 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 12037-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 61 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
NIH/3T3 cells, HepG2 cells

Positive IP detected in:
MCF-7 cells

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
dishevelled, dsh homolog 2 (Drosophila)

Calculated molecular weight:
736aa,79 kDa

Observed molecular weight:
90-95 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DVL2

Synonyms
Dishevelled 2, DSH homolog 2, DVL2
Background

DVL2 is member of the dishevelled (dsh) protein family. DVL2 encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein in a variety of cell lines and species. DVL2 participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. It promotes internalization and degradation of frizzled proteins upon Wnt signaling. It plays a role both in canonical and non-canonical Wnt signaling. It also Plays a role in the signal transduction pathways mediated by multiple Wnt genes.


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