ERC1 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 22211-1-AP

Featured Product KD/KO validated

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Con: 70 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HeLa cells, COLO 320 cells, human testis tissue, Jurkat cells

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:2000
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ELKS/RAB6-interacting/CAST family member 1

Calculated molecular weight:
1116aa,128 kDa

Observed molecular weight:
124-135 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ERC1

Synonyms
Cast2, ELKS, ERC 1, ERC1, KIAA1081, Rab6 interacting protein 2, RAB6IP2
Background

ERC is an acronym based on previous separate namings of members of this protein family, ELKS, Rab6IP2 and CAST (PMID: 12391317). They are known to bind RIMs, the active zone proteins that regulate neurotransmitter release. ERC1 (ELKS) is an essential regulatory subunit of the IKK complex and likely functions by recruiting IκBα to the complex (PMID: 15218148). Multiple isoforms of ERC1 mRNA are generated by alternative splicing (PMID: 12203787). There are two known splice variants of ERC1 protein that differ at their C termini, ERC1a and ERC1b. ERC1a is ubiquitously expressed, whereas ERC1b is brain-specific (PMID: 12391317; 12923177).


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