EXOSC10 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 16731-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 36 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HeLa cells,mouse spleen tissue

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human spleen tissue,human heart tissue, human testis tissue, human ovary tissue, human liver tissue, human kidney tissue

Positive IF detected in:
HeLa cells, NIH/3T3 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
exosome component 10

Calculated molecular weight:
885aa,101 kDa

Observed molecular weight:
100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
EXOSC10

Synonyms
Autoantigen PM/Scl 2, EXOSC10, exosome component 10, p2, p3, p4, PM Scl, PM/Scl 100, PMSCL, PMSCL2, RRP6, Rrp6p
Background

About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a neuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl 2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl paitents. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.


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