EXOSC2 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66099-1-Ig |CloneNo.: 1G8B1

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Con: 190 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Jurkat cells, HEK-293 cells, HeLa cells, HepG2 cells

Positive IHC detected in:
human liver tissue, human skin cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
exosome component 2

Calculated molecular weight:
33 kDa

Observed molecular weight:
33kD

GenBank accession number:

Gene ID (NCBI):

Gene symbol
EXOSC2

Synonyms
EXOSC2, exosome component 2, hRrp4p, p7, RRP4, Rrp4p
Background

In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snoRNA and snRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs [PMID:15346807]. EXOSC2 is a non-catalytic component of the RNA exosome complex that has 3'->5' exoribonuclease activity and involves in a multitude of cellular RNA processing and degradation events [PMID: 17545563].


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