FAS/CD95 Antibody 1 Publications

Mouse Monoclonal| Catalog number: 60196-1-Ig |CloneNo.: 1G7F7

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Freight/Packing

Con: 170 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
Jurkat cells, HeLa cells, K-562 cells, U-937 cells

Positive IHC detected in:
human tonsillitis tissue, human colon cancer tissue, human tonsillitis tissue

Positive FC detected in:
Jurkat cells

Recommended dilution:
WB : 1:1000-1:8000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Fas (TNF receptor superfamily, member 6)

Calculated molecular weight:
35-38 kDa

Observed molecular weight:
38-45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FAS

Synonyms
ALPS1A, APO 1, Apo 1 antigen, APT1, CD95, FAS, FAS1, FASLG receptor, FASTM, TNFRSF6
Background

FAS, also named as CD95, APO-1, APT1, FAS1 and TNFRSF6, is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily, can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand.


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