FIS1 Antibody 35 Publications

Rabbit Polyclonal| Catalog number: 10956-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 50 μg/150 μl

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Species specificity:
human, mouse, rat, pig

Positive WB detected in:
HeLa cells, A431 cells, human heart tissue, mouse thymus tissue, human spleen tissue, HEK-293 cells, rat brain tissue, rat heart tissue, mouse heart tissue, mouse brain tissue, COLO 320 cells, pig brain tissue, SH-SY5Y cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human brain tissue, human brain tissue, human prostate cancer tissue

Positive IF detected in:
Hepa1-6 cells

Recommended dilution:
WB : 1:1000-1:16000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:10-1:100
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)

Calculated molecular weight:
17 kDa

Observed molecular weight:
17 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FIS1

Synonyms
CGI 135, FIS1, FIS1 homolog, hFis1, TPR repeat protein 11, TTC11
Background

Fis1 (fission 1) is an integral mitochondrial outer membrane protein that participates in mitochondrial fission by interacting with dynamin-related protein 1 (Drp1). Excessive mitochondrial fission is associated with the pathology of a number of neurodegenerative or neurodevelopmental diseases. Increased expression of Fis1 has been found in Huntington’s disease (HD)-affected brain, Alzheimer’s disease (AD) patients, and autism spectrum disorder. This antibody was raised against the full-length of human Fis1 protein, and recognizes endogenous Fis1 protein in various lysates. (21257639, 21459773, 23333625)


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