G3BP1 Antibody 18 Publications

Rabbit Polyclonal| Catalog number: 13057-2-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 43 μg/150 μl

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Species specificity:
human, rat, mouse

Positive WB detected in:
A431 cells,Neuro-2a cells, human brain tissue, HepG2 cells, MCF-7 cells, rat brain tissue, HeLa cells, HEK-293 cells, Jurkat cells, C6 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human testis tissue, human breast cancer tissue, human skeletal muscle tissue, human testis tissue

Positive IF detected in:
HeLa cells, Ethacrynic acid treated HepG2 cells, HepG2 cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
GTPase activating protein (SH3 domain) binding protein 1

Calculated molecular weight:
466aa,52 kDa

Observed molecular weight:
55-60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
G3BP1

Synonyms
G3BP, G3BP 1, G3BP1, HDH VIII
Background

GAP SH3 Binding Protein 1 (G3BP1), also named as G3BP, is an effector of stress granule (SG) assembly. SG biology plays an important role in the pathophysiology of TDP-43 in ALS and FTLD-U. G3BP1 can be used as a marker of SG. It has been shown to function downstream of Ras and play a role in RNA metabolism, signal transduction, and proliferation. G3BP1 is a ubiquitously expressed protein that localizes to the cytoplasm in proliferating cells and to the nucleus in non-proliferating cells. G3BP1 has recently been implicated in cancer biology.


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