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GJB3 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 12880-1-AP

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Con: 36 μg/150 μl

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Tested Applications
Applications:
ELISA, IF, IHC, IP, WB
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Images See all

12880-1-AP;mouse ovary tissue

mouse ovary tissue were subjected to SDS PAGE followed by western blot with 12880-1-AP(GJB3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours

12880-1-AP;HeLa cells

IP result of anti-GJB3(IP:12880-1-AP, 4ug; Detection:12880-1-AP 1:500) with HeLa cells lysate 2600 ug

12880-1-AP;human cervix tissue

Immunohistochemistry of paraffin-embedded human cervix tissue slide using 12880-1-AP( GJB3 Antibody) at dilution of 1:50 (under 10x lens)

12880-1-AP;human cervix tissue

Immunohistochemistry of paraffin-embedded human cervix tissue slide using 12880-1-AP( GJB3 Antibody) at dilution of 1:50 (under 40x lens)

12880-1-AP;HeLa cells

Immunofluorescent analysis of ( -20℃ Ethanol ) fixed HeLa cells using 12880-1-AP(GJB3 antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Species specificity:
human, mouse, rat, marmosets
Positive WB detected in:
mouse ovary tissue, HeLa cells, human brain tissue, human heart tissue
Positive IP detected in:
HeLa cells
Positive IHC detected in:
human cervix tissue, human cervix tissue, human ovary tumor tissue, human skin cancer tissue
Positive IF detected in:
HeLa cells
Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
GJB3 fusion protein Ag3839
Full name:
gap junction protein, beta 3, 31kDa
Calculated molecular weight:
270aa,31 kDa
Observed molecular weight:
31 kDa
GenBank accession number:
BC012918
Gene ID (NCBI):
2707
Gene symbol
GJB3
Synonyms
Connexin 31, CX31, DFNA2, DFNA2B, EKV, FLJ22486, Gap junction beta 3 protein, GJB3
Background

GJB3, also known as Connexin-31 (Cx31), belongs to the connexin family. Connexins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. Mutations in the gene of GJB3 have been described in patients with dominant and recessive hearing impairment and in patients with erythrokeratodermia variabilis (EKV).


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