Glutamate receptor 2 Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 11994-1-AP

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Freight/Packing

Con: 63 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue, human brain tissue, SKOV-3 cells

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
mouse brain tissue

Positive FC detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
glutamate receptor, ionotropic, AMPA 2

Calculated molecular weight:
883aa,99 kDa

Observed molecular weight:
94-105 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GRIA2

Synonyms
GluA2, GluR 2, GluR B, GluR K2, GLUR2, GLURB, Glutamate receptor 2, GRIA2, HBGR2
Background

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. GRIA2 (glutamate receptor 2, GluR-2) belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. These channels are assembled from 4 related subunits, GRIA1-4. The presence of GRIA2 in the heteromeric AMPA receptors impermeabilizes it to calcium, preventing possible calcium-mediated toxicity.


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