GZMB Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 13588-1-AP

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Con: 23 μg/150 μl

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Species specificity:

Positive WB detected in:
HL-60 cells

Positive IHC detected in:
human lymphoma tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Purification method:
Antigen affinity purification


PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Calculated molecular weight:
247aa,28 kDa

Observed molecular weight:
33 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

CCPI, CGL 1, CGL1, CSP B, CSPB, CTLA1, CTSGL1, Endogenous granzyme B, Granzyme B, GZMB, HLP, SECT

GZMB(Granzyme B) is also named as CGL1, CSPB, CTLA1, GRB and belongs to the Granzyme subfamily. This enzyme is necessary for target cell lysis in cell-mediated immune responses. The cytotoxic lymphocyte protease granzyme B (GzmB) can promote apoptosis through direct processing and activation of members of the caspase family. GzmB can also cleave the BH3-only protein, BID, to promote caspase-independent mitochondrial permeabilization(PMID:17283187).GzmB induces laminB degradation in isolated nuclei less efficiently than GzmA(PMID:11331782).This full length protein has 2 glycosylation sites and a signal peptide.Unglycosylated human granzyme B is 26 kDa and g high mannose glycosylated is 32 kDa and only 32kDa or smaller forms of granzyme B are accumulated within nuclei(PMID:8626751).

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