HGS Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 10390-1-AP

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Freight/Packing

Con: 45 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HeLa cells, HEK-293 cells, K-562 cells

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human liver tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
hepatocyte growth factor-regulated tyrosine kinase substrate

Calculated molecular weight:
86 kDa

Observed molecular weight:
110-115 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HGS

Synonyms
HGS, HRS, Protein pp110, ZFYVE8
Background

Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS, synonyms: HRS, ZFYVE8) is a 110 to 115-kDa zinc finger phosphotyrosine protein inducible by stimulation with interleukin 2 (IL-2), granulocyte-macrophage colony-stimulating factor (GM-CSF) as well as hepatocyte growth factor (HGF), and is associated with signal-transducing adaptor molecule (STAM). HGS suppresses DNA synthesis upon stimulation with IL-2 and GM-CSF, counteracting the function of STAM which is critical for cell growth signaling mediated by the cytokines. HGS also interacts with the neurofibromatosis 2 tumor suppressor protein schwannomin/merlin. The growth suppression activity of schwannomin/merlin requires HGS and the binding of schwannomin/merlin to HGS facilitates its ability to function as a tumor suppressor, probably by inhibiting STAT activation.


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