IFITM2/3 Antibody 3 Publications

Mouse Monoclonal| Catalog number: 66081-1-Ig |CloneNo.: 2E8D12

Featured Product KD/KO validated

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Con: 128 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Hela cells, HeLa cells, human placenta tissue

Positive IHC detected in:
human lung cancer tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
interferon induced transmembrane protein 3 (1-8U)

Calculated molecular weight:

Observed molecular weight:
14 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IFITM3

Synonyms
1 8U, IFITM3, IP15
Background

IFITM3, also named as interferon-inducible protein 1-8U, belongs to the CD225 family. It is IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus, by inhibiting the early steps of replication. IFITM3 is identified as interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. IFITM3, the most potent antiviral IFITM, was found to inhibit an uncharacterized early infectious event after VSV endocytosis, but before primary transcription of its viral genome. IFITM proteins are viral restriction factors that can inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. They differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression. This antibody recognizes both IFITM2 and IFITM3.


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