IGF2R-Specific Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 20253-1-AP

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Freight/Packing

Con: 63 μg/150 μl

Choose size:

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Species specificity:
human

Positive WB detected in:
HepG2 cells, A431 cells, L02 cells

Positive IP detected in:
HepG2 cells

Positive IHC detected in:
human liver cancer tissue, human liver tissue, human liver cancer tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
insulin-like growth factor 2 receptor

Calculated molecular weight:
274 kDa

Observed molecular weight:
274 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IGF2R

Synonyms
CD222, CI Man 6 P receptor, CI MPR, CIMPR, IGF II receptor, IGF2R, M6P R, M6P/IGF2 receptor, M6P/IGF2R, M6PR, MPR 300, MPR1, MPRI
Background

IGF2R, also named as MPRI, CI Man-6-P receptor, CI-MPR, M6PR, IGF-II receptor, M6P/IGF2R, MPR 300 and CD222, belongs to the MRL1/IGF2R family. IGF2R transports of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. IGF2R is a lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. IGF2R acts as a positive regulator of T-cell coactivation, by binding DPP4. The antibody is specific to IGF2R.


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