JUNB Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 10486-1-AP

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Freight/Packing

Con: 41 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
MCF7 cells,C6 cells, HeLa cells, HT-1080 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human gliomas tissue, human ovary tissue, human testis tissue

Positive IF detected in:
MCF-7 cells, HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
jun B proto-oncogene

Calculated molecular weight:
36 kDa

Observed molecular weight:
42 kDa, 43 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
JUNB

Synonyms
AP 1, jun B proto oncogene, JUNB, Transcription factor jun B
Background

JunB is one of the components of the Activator Protein-1 (AP-1) transcription complex that have been implicated in the control ofthe G0/G1 transtion in fibroblasts. AP-1 is a collection of dimers formed by members of the Jun-, Fos-, ATF- and Maf multigene families that bind to specific DNA regulatory elements called AP-1/12-O-tetradecanoylphorbol-13-acetate-responsive elements (TREs) and cAMP-responsive elements (CREs). JunB binds to the DNA sequence 5'-TGA[CG]TCA-3', and involves in the regulation of gene activity following the primary growth factor response. It also acts either as a tumor suppressor or as an oncogene depending on the cell and physiopathological context


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