Plakoglobin/gamma catenin Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 11146-1-AP

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Freight/Packing

Con: 40 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse heart tissue,human heart tissue, HeLa cells, T-47D cells, A431 cells

Positive IHC detected in:
human pancreas cancer tissue, human breast cancer tissue, human colon cancer tissue, human skin tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
junction plakoglobin

Calculated molecular weight:
82 kDa

Observed molecular weight:
82 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
JUP

Synonyms
γ-Catenin, ARVD12, Catenin gamma, CTNNG, Desmoplakin 3, Desmoplakin III, DP3, DPIII, junction plakoglobin, JUP, gamma Catenin, PDGB, PKGB
Background

Plakoglobin (γ-catenin), a member of the Armadillo proteins, plays important roles in cell adhesion with α-catenin and β-catenin, is involved in Wnt signaling, and is translocated into the nucleus and binds LEF1. Plakoglobin is a major cytoplasmic component of both desmosomes and adherens junctions, and is the only known constituent common to submembranous plaques in both of these structures, which are located at the intercalated disc (ICD) of cardiomyocytes. Plakoglobin links cadherins to the actin cytoskeleton. Mutations in plakoglobin are associated with arrhythmogenic right ventricular dysplasia and Pemphigus vulgaris.


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